The Brijuni Conferences bring an up-to-date perspective of the present state of a given topic with the fundamental scientific philosophy to stimulate a cross-disciplinary flow of knowledge and expertise from both the science and technology standpoints. The topic of the conference is to discuss some of the major challenges for humans settling in Space that must be explored by the tools of science and technology. At the hearth of these challenges are communication, navigation and propulsion. New ideas that meet these challenges shall be discussed in the interdisciplinary spirit and informal flow of ideas.